Antimicrobial Resistance Management

Antimicrobial resistant organisms are considered one of today’s most serious global threats to human health. They lead to high morbidity and mortality, as well as economic burden. To fight the increase and spread of these organisms, we must take action on a number of fronts with proven, reliable strategies and leading-edge tools. bioMérieux is your trusted microbiology partner for complete, integrated microbial solutions to manage antibiotic resistance.

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The global threat that can’t be ignored

Burden of antimicrobial resistant infections
 

Estimated infections annually:
2 million in US1; 400,000 in Europe2

Estimated economic burden:
$20 billion1 direct costs in the USA; €1-5 billion in Europe2

 

1) Antibiotic Resistance Threats in the United States, CDC 2013
2) ENVI 2013 European Report on patient safety

Since their introduction in early 20th century, antibiotic drugs have greatly reduced illness and death to the benefit of human health. Yet, particularly due to over-prescription of antibiotics, many infectious organisms have adapted and become resistant to 1st-line and even 2nd-line antibiotics. A number of drug resistant organisms, including Enterobacteriaceae (CRE), Campylobacter and Candida, show continually increasing levels of resistance. Some organisms are even resistant or becoming resistant to virtually all antibiotics, such as carbapenem-resistant Enterobacteriaceae (CRE) and Multidrug-resistant Acinetobacter. Illnesses linked to resistance pose a great burden on health systems and society in general1:

  • Treatment options are unavailable or limited; available antibiotics may be less effective, more expensive and sometimes harmful to patients
  • Resistance means higher mortality risk, longer hospital stays, delayed recuperation, and sometimes long-term disability for patients
  • Drug resistant organisms are behind many outbreaks of healthcare associated infection
  • While the problem of antimicrobial resistant organisms is most acute in the healthcare setting, there is strong evidence that transmission is increasing in the community

Health experts and agencies around the world agree: antimicrobial resistance is an urgent, global threat that can’t be ignored. The WHO says that “urgent action is required at the highest political level, globally and at country level”2. The consequences of inaction are, as stated by the CDC, “potentially catastrophic”1.

  1. Antibiotic Resistance Threats in the United States, CDC 2013
  2. Antibiotic resistance - a threat to global health security and the case for action, Side-event at the Sixty-sixth WHA, May 2013

 

Challenge: How to respond effectively?

The main offenders
 

Urgent Threats

  • Clostridium difficile
  • Carbapenem-resistant Enterobacteriaceae (CRE)
  • Drug-resistant Neisseria gonorrhoeae

Serious Threats

  • Multidrug-resistant Acinetobacter
  • Drug-resistant Campylobacter
  • Fluconazole-resistant Candida (a fungus)
  • Extended spectrum β-lactamase-producing Enterobacteriaceae (ESBLs)
  • Vancomycin-resistant Enterococcus (VRE)
  • Multidrug-resistant Pseudomonas aeruginosa
  • Drug-resistant Non-typhoidal Salmonella
  • Drug-resistant Salmonella Typhi
  • Drug-resistant Shigella
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Drug-resistant Streptococcus pneumoniae
  • Drug-resistant tuberculosis

Concerning Threats

  • Vancomycin-resistant Staphylococcus aureus (VRSA)
  • Erythromycin-resistant Group A Streptococcus
  • Clindamycin-resistant Group B Streptococcus

 

Antibiotic Resistance Threats in the United States, CDC 2013

In the fight against antimicrobial resistant organisms, healthcare providers and public health bodies must take a multi-pronged approach: prevention, treatment, outbreak management, tracking and education. To ensure you can respond effectively on every level, you need commitment from all those involved, complete and reliable information, and relevant, timely tools.

Prevention

  • Infection control
    • Screening and active surveillance
    • Hygiene policy
  • Antimicrobial Stewardship Programs
  • Environmental control

Treatment

  • Differentiation of bacterial from viral infection
  • Informed decisions for relevant antibiotic use
    • Rapid tests
    • Reliable identification of bacteria
    • Antimicrobial resistance testing
  • Flexible testing methods for different healthcare/clinical situations
    • Easy to read and interpret results

Outbreak management & tracking

  • Rapid detection of resistance mechanisms
  • Complete epidemiological data tracking
  • Good information flow

Education

  • Collaborative action at the local, national and international levels
  • Continuing education for healthcare professionals
  • Accurate, easy-to-access patient education

 

Solution: Easy-to-implement, global solutions

The common thread among the various needs for effective antimicrobial resistance management is that you need easy-to implement global solutions for actionable results.

As both a pioneer and innovator in resistance detection and susceptibility testing, bioMérieux works closely with its healthcare partners to give you the solutions you need. We aim for the flexibility to meet different needs in different types of lab and healthcare settings. We value the integration of automation in the laboratory because it offers improved time-to-results and standardization; simpler reading and interpretation; faster information transmission; and better data tracking and management. Designed and continually improved through expert research and innovation, our instruments and reagents offer rapid, reliable, standardized results.

 

 
Requirement
 
 
bioMérieux solution
 
Infection control/Prevention Environmental control range
Identification VITEK® 2
VITEK® MS
API®
Antimicrobial susceptibility testing VITEK® MS
VITEK® 2
Advanced Expert System (AES)
Etest®
Confirmation Etest®
Screening, active surveillance & ongoing treatment NucliSENS easyQ®
chromID® CARBA SMART
chromID® MRSA SMART
chromID® MRSA/S. aureus biplate
chromID® ESBL
chromID® VRE
VIDAS® B.R.A.H.M.S PCT
bioNexia® Strep A
bioNexia® Influenza A+B
Outbreak management NucliSENS easyQ®
Diversilab®
VIGIguard™ & Myla®
Education Be Smart with Resistance™

 

Solution: A partner you can trust

bioMérieux knows labs

With more than 50 years’ experience working with microbiology labs, we’ve been at your side throughout the evolution of the challenges you face, including the onset of antimicrobial resistance.Your challenges are our challenges.

bioMérieux goes beyond bringing you best-in-class instruments and reagents specifically designed to meet the laboratory challenges posed by microbial resistant organisms. We actively foster collaboration, standing alongside international and national health organizations, policy-makers, healthcare facility and laboratory leaders and frontline medical professionals. We are a partner you can trust because our prime motivation is the same as yours: protecting and improving human health worldwide.

We believe in an integrated approach to health challenges. Our flagship campaign in the fight against antimicrobial resistant organisms is Be S.M.A.R.T. with Resistance™ .Along with a portfolio of microbiology solutions for prevention, tracking and screening, be S.M.A.R.T. initiatives include information, education and events related to the antimicrobial resistance threat. Some examples:

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