DiversiLab®

Automated rapid strain typing platform

Help ensure effective infection control with this automated system for rapid strain typing solutions

  • Strain typing for real-time investigations: results in approximately 4 hours
  • Strain level discrimination for bacteria and fungi
  • Track contamination source and spread
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Automated Strain Typing

The DiversiLab® system is an automated platform that uses rep-PCR* technology to provide standardized, reproducible DNA fingerprinting and analysis of bacterial and fungal samples for complete isolate characterization.

  • Track the spread and source of microbial infections, contaminations or epidemics
  • Rapidly and accurately distinguish microbial isolates at the subspecies and strain level
  • Automated system also makes strain typing feasible for routine use, even with numerous specimens

*rep-PCR: amplification of non-coding repetitive sequences interspersed throughout the bacterial genome using Polymerase Chain Reaction (PCR). 
*DiversiLab is not for diagnostic use.

Fast Tracking & Knowledge at Your Fingertips

With strain typing results and automated data analysis in approximately four hours, the DiversiLab® system puts knowledge at your fingertips.

  • Fast identification and tracking of potential microbial infections, contaminations or epidemics:
    • Helps enable you to quickly control spread and reduce human and economic burden of HAI
  • Automated analysis:
    • Interactive reports for easy data interpretation
    • Multiple data viewing including dendrogram, similarity matrix, graph overlay & scatter plot
  • Compare results:
    • With your own database
    • Between samples (same patient or different patients)
    • With the extensive, easy-to-use DiversiLab® on-line database
  • Trends analyses:
    • Database samples for long-term studies
    • Track seasonal outbreaks from year to year
  • Complete data management for reporting, quality assurance & compliance.

 

the DiversiLab® system

bioMérieux’s Complete Offer in Infection Control

bioMérieux has more than 50 years’ experience in microbiology and is recognized for expertise in culture, identification and susceptibility testing. With our extensive offer of microbiology solutions, including the innovative DiversiLab® genotyping system, bioMérieux brings you the systems needed to support decisions that can ultimately help reduce the number of HAI and ensure appropriate use of antibiotic therapy.

 

DiversiLab® reagents, equipment & software for microbial genotyping of bacteria and fungi

DiversiLab®: Reagents:

  • 28 Fingerprinting Kits for majority of routinely isolated organisms.
  • Quality-controlled and optimized for precise genotyping results.
  • Easy-to-use genotyping format maintains a consistent procedure for each organism.

Genus-specific Fingerprinting Kits (24 tests):

Gram Positive Gram Negative Miscellaneous
Bacillus (410962)
Bifidobacterium (410963)
Clostridium (410966)
C. perfringens (410967)
Enterococcus (410969)
Lactobacillus (410982)
Staphylococcus (410991)
Streptococcus (410992)
Acinetobacter (410946)
Archaea (410948)
Campylobacter (410964)
Enterobacter (410968)
Escherichia (410980)
Francisella (410993)
Klebsiella (410981)
Listeria (410983)
Pseudomonas (410988)
Salmonella (410989)
Serratia (410990)
Mycobacterium (410984)
M. tuberculosis (410986)
Mycoplasma (410985)
Propionibacterium (410987)
Fungal
Aspergillus (410949)
Candida (410965)
Saccharomyces (410994)

General Fingerprinting Kits:

Bacterial (411007)
Fungal (411008)

DiversiLab® Chip and Reagents:

  • Use microfluidics LabChip® technology to detect amplicon resulting from amplification with fingerprinting kit.
  • Reproducible, consistent results can be compared across experiments.
  • Runs 13 samples in less than one hour.
  • DiversiLab® LabChip Kit includes the chips and reagents for 325 tests.

 MO BIO UltraClean® Microbial DNA Isolation Kit:

  • UltraClean® kit is recommended for extraction of microbial genomic DNA.
  • Standardized extraction procedure for all organisms including Bacteria (Gram positive and Gram negative), Mycobacterium and Fungi.
  • Clean and high yield DNA sample (mechanical lysis and column-based method) validated and QCed for use in the DiversiLab® System.
  • Extraction kits in 50- and 250- test sizes.

 Quantitation of DNA:

  • A normalized genomic DNA concentration is recommended as an addition to the rep-PCR reaction.
  • DNA quantitation with a spectrophotometer (such as Nano-Drop or BioPhotometer) is highly recommended. 
  • Option to spectrophotometer: bioMérieux provides genomic DNA standards to be run on a gel along with the test samples to ensure both DNA quantity and quality.

DiversiLab® EQUIPMENT:  

Hardware included with the DiversiLab® System:

  • Agilent 2100 Electrophoresis Bioanalyzer
  • Desktop Computer with Flat Panel Monitor
  • Microfluidics LabChip Accessories
System specifications for the Agilent 2100 Bioanalyzer
Weight 10 kg (22 lbs)
Dimensions
(W x D x H)
162 x 412 x 290 mm
(6.4 x 16.2 x 11.4 in)
Line voltage 100 – 240 VAC+10%
Line frequency 50-60 Hz+5%
Power consumption (max) 30 W / 60 VA
Ambient operating temperature 5 – 40oC (41 – 104oF)
Ambient non-operating temperature 40o – 70oC (-40o– 158oF)
Humidity <80%, at 5-31oC (41-89oF)
,Decreasing linearly to 50% at 40oC (104oF)
Operating altitude Up to 2000 m (6500 ft)
Non-operating altitude Up to 4600 m (14950 ft)
Safety standards: IEC, CAS, UL Installation Category II, Pollution Degree 2

 

DiversiLab® SOFTWARE:  

DiversiLab® Software

Software included with the DiversiLab® System:

  • DiversiLab® Software
  • Agilent Expert
  • Diversilab Data Transfer Client

The secure web-based DiversiLab® software supports every step of the rep-PCR workflow process. It is automated and offers a variety of tools for easy, accurate data analysis, worksheet generation, quality assurance and data management.

Secure web-based application.

  • Intuitive, easy-to-use interface with multiple analysis and data management tools.
  • Analysis tools to help track isolates through differentiation of species, subspecies and strains include:
    • Dendrogram: “Tree-like” display of fingerprint similarities for visualization of sample clustering.
    • Similarity matrix: Color-coded percentage of similarity between pairs.
    • Graph overlay: Shows small differences between samples.
    • Scatter plot: Two-dimensional “birds-eye-view” shows relative sample similarities between rep-PCR profiles.
  • Automated end-to-end data management.
  • Flexible, customizable report and analysis options.
  • Available as full system or as an add-on to an Agilent 2100 bioanalyzer system.

 

 

Please contact your local bioMérieux representative for product availability.

 

DiversiLab®: Publications

Antibiotic-Resistant Bacteria

Other Bacteria

Fungi

Mycobacteria

Reviews

BBCI Posters

Customer Posters

Healthcare publications

Other publications:

U.S. Department of Health and Human Services Centers for Disease Control and Prevention (CDC)
Guidelines for Environmental Infection Control in Health-Care Facilities

Ducel G, Fabry J, Nicolle L, eds.
Prevention of hospital-acquired infections: a practical guide.
Second edition (WHO document WHO/CDS/CSR/EPH/2002.1.2). Geneva, World Health
Organization, Department of Epidemic and Pandemic Response, 2002

 

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