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Infectious Diseases

 

Sepsis

Every year, severe sepsis strikes more than 750,000 people in the United States, 215,000 of whom die. Sepsis with acute organ dysfunction (severe sepsis) is the leading cause of death in the non-coronary intensive care unit (1). Despite the enormous investment in critical care resources, severe sepsis mortality ranges from 28% to 50% or greater.


Early diagnosis of sepsis is key for improved survival


FDA Clears bioMérieux's VIDAS® B.R.A.H.M.S PCT Assay
A First Indication for Sepsis Risk Assessment in the ICU


Since the microbiological origin of infection is only demonstrated in about 2/3rd of cases, an expanded list of clinical and laboratory variables need to be taken into account for diagnosis, prognosis and monitoring response to therapy. Together, these variables help assess the severity of the inflammatory response and organ dysfunction. Host response biomarkers such as procalcitonin (PCT) and C-reactive protein (CRP) are now being recognized as useful tools in the diagnostic process. 1. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-10.




bioMérieux solutions for diagnosing sepsis

  • Blood cultures: BacT/ALERT® 3D modular range of automated blood culture systems for real-time monitoring of blood samples. 
     
  • Identification and antibiotic susceptibility testing:
    • VITEK 2 and VITEK 2 Compact: range of fully automated identification and susceptibility testing systems
    • Etest®: gradient technique for on-scale determination of MIC values for antibiotics, antifungal and antimycobacterial agents
       
  • Procalcitonin (new marker of bacterial infection):
    VIDAS® B.R.A.H.M.S. Procalcitonin is an automated test for early diagnosis and monitoring of sepsis and bacterial infection and is adapted to emergency situations (visit also: www.procalcitonin.com).