ARGENE® Respiratory range

Real-time PCR detection kits for viral respiratory diseases

  • Complete and ready-to-use kits
  • Validated on major extraction and amplification platforms
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ARGENE® Respiratory advantages

  • Modular multiplex solution
    • Targeted diagnostic strategy with an “à la carte” menu
    • Choose which pathogens to test depending on the season
    • Allow the diagnosis of co-infections
  • Sensitive and reproducible
    • Reliable detection of infectious agents involved in viral respiratory diseases
    • All controls included (positive control, negative control, internal control)
    • Internal control is an endogenous internal control to check for extraction/amplification process and sample quality
  • Flexible
    • Validated for use with various upper and lower respiratory samples 
    • For use on manual workflow or on automated ARGENE® SOLUTION workflow
    • Validated for use on major extraction and amplification platforms



Everything you need in one kit

R-GENE® kits include all necessary reagents:

Ready-to-use amplification premix (including Taq polymerase)

Reverse transcriptase

Positive control

Negative control

 

Easy procedure

Using R-GENE® assay is easy.

  SARS-COV-2/FLUA/FLUB/RSV R-GENE® COVID-19R-GENE® RHINO&EV/CcR-GENE®
Ordering information  Reference:

424433

Designation:

SARS-COV-2/FLUA/FLUB/RSV R-GENE®
Reference:

424017

Designation:

COVID-19 R-GENE®
Reference:

71-042

Designation:

Rhino&EV/Cc R-GENE®
Test principle   Real Time PCR Detection kit  
Technology   Real-Time PCR / 5’ nuclease technology  
PCR design 5-PLEX PCR

1. SARS-CoV-2

2. Influenza A

3. Influenza B

4. RSV

5. Endogenous Internal Control
2-PLEX PCR

1. SARS-CoV-2

2. Endogenous Internal Control
2-PLEX PCR

1. Rhino&EV

2. Endogenous Internal Control
Targeted genes

SARS-CoV-2: N & RdRp genes

Influenza A: M gene

Influenza B: M gene

RSV: M gene

Endogenous Internal Control: HPRT1 gene

SARS-CoV-2: N & RdRp genes

Endogenous Internal Control: HPRT1 gene

Rhinovirus A/B/C: non coding 5' region

Enterovirus A/B/C/D: non coding 5' region

Endogenous Internal Control: HPRT1 gene

Specimens Nasopharyngeal Swab Nasopharyngeal Swab

Saliva
Nasopharyngeal Swab Nasopharyngeal Aspirate Bronchoalveolar Lavage
Extraction platforms EMAG®

NUCLISENS® easyMAG® QIAsymphony SP

MagNA Pure 96

MGISP 960
EMAG®

NUCLISENS® easyMAG® QIAsymphony SP

MagNA Pure 96

MGISP 960
EMAG®

NUCLISENS® easyMAG® QIAsymphony SP
Amplification platforms   QuantStudio 5

QuantStudio 5 Dx

CFX96

CFX Opus 96
QuantStudio 5

QuantStudio 5 Dx

CFX96

CFX Opus 96

7500 Fast

7500 Fast Dx

LightCycler 480 (System II)
QuantStudio 5

QuantStudio 5 Dx

CFX96

CFX Opus 96

7500 Fast

7500 Fast Dx

LightCycler 480 (System II)
Kit content   All included (amplification premix, reverse transcriptase, positive control, negative control)  
Controls included   Positive Control, Negative Control, Endogenous Internal Control  
Number of tests 96 tests 96 tests 60 tests
Storage conditions   -15°C / -31°C  
Status For In Vitro Diagnostic use (CE marked under EU regulation 2017/746) For In Vitro Diagnostic use (CE marked under EU directive 98/79/CE) For In Vitro Diagnostic use (CE marked under EU regulation 2017/746)

 

Fast facts on Respiratory Pathogens

What are Respiratory Pathogens?

The vast majority of respiratory illnesses are caused by viruses and bacteria. In both children and adults, acute respiratory infections (ARI) are most frequently due to infections with Influenza A and B viruses, Parainfluenza viruses 1, 2 and 3, Respiratory Syncytial Virus (RSV A and B), Adenoviruses and Rhinoviruses. Others pathogens such as Coronaviruses, Bocaviruses, Enteroviruses, Parainfluenza 4, human Metapneumovirus, Mycoplasma pneumoniaChlamydia pneumoniae, Legionella pneumophila, Bordetella pertussis and Bordetella parapertussis also infect the respiratory tract and can cause various diseases from mild self-limiting upper respiratory infections to potentially threatening pneumonia.

Who is most at risk?

Anyone can become infected and ill with these respiratory pathogens. However, young children, the elderly, immunocompromised or weakened individuals (including those with chronic disease, cancer, or in intensive care) are most likely to suffer serious and potentially life-threatening pneumopathies.

What are the benefits of Respiratory pathogens molecular testing?

Clinical symptoms for different respiratory illnesses are similar so in vitro diagnostic molecular methods are necessary to determine the causative agents. Early, rapid and specific detection of the virus or bacteria involved using real-time PCR methods is essential to provide patient-tailored therapy for better outcomes. An accurate diagnosis will also help to control outbreaks, reduce potential antibiotic resistance and facilitate a more rapid patient recovery.

ARGENE® Respiratory: PUBLICATIONS & POSTERS

Infections respiratoires aigües : étude comparative des trousses d’amplification génique en temps réel respiratory multi well system r-gene de BioMérieux et Respiratory pathogens 21 de Fast Track diagnostics.

Trombert-Paolantoni S., Hedbaut E., Clairet V

RICAI 2015

 

Pattern of Respiratory Pathogen Nasal Colonization in the first year of life in Healthy Infants and Infants with Cystic Fibrosis

Insa Korten et al.

Poster ESCV 2016

 

BioMérieux molecular workflow : solution for ARGENE® product range automation

Bourdin Jérôme; Levillain Erwan; Bes Jérôme; Guy Michel; Margry Pascal; Bufflier Emmanuel; Chini Giorgio; Pradier Nicolas; Magro Stephane; Brengel-Pesce Karen

Poster ESCV 2014

Development of a new MWS r-gene Real Time PCR for the detection of Legionella pneumophila

Cécile Résa; Bertrand Marina; Dubé Manon; Pourqué Laure ; Magro Stéphane , Barranger Côme and Joannes Martine

ESCV 2014


 

bioMérieux Argene Range verifications on the ViiA7 (Fast and Standard Blocks) and ABi 7500 Fast Dx Real Time PCR Platforms

(Magro Stephane; Delarivière Audrey; Berriot Aurelie; Turc Amelie; Moiroud Elise; Derome Andrew; Alberti-Segui Cristina; Grosz Sophie; Vidal Celine; Poyet-Gelas Fanny and Barranger Come)

ESCV 2014


 

Mobile phone use in health care units as potential vectors of viral infections

Sylvie Pillet et al, University Hospital Saint-Etienne

ESCV 2014


 

Comparative Evaluation of Six Commercialized Multiplex PCR Kits for the Diagnosis of Respiratory Infections

Pillet et al.

PLOS 2013.


 

Use of of Influenza Duplex PCR according Lean management to improve response to influenza pandemic and epidemic surge in a hospital virology department.

Casalegno JS, Bouscambert M, Valette M, Billaud G, Emilie F, Escuret V, Mekki Y, Morfin F, Lina B.

HCL Lyon & Laboratoire de Virologie Lyon-Est, Bron, France

Option VIII, Cape Town, South Africa 2013


 

Evaluation des performances de la trousse Chla/Myco pneumo r-gene (Argène/bioMérieux) pour la détection de Mycoplasma pneumoniae par PCR en temps réel

Tanguy Flao et al.

USC Infections humaines à mycoplasmes et à chlamydiae, CNR des infections à chlamydiae

RICAI 2013


 

Respiratory Viruses In Hospitalised Adults In Bern, Switzerland During The 2012/2013 Season

Maria Teresa Barbani et al

Institute for Infectious diseases, University of Bern, Switzerland

ECV 2013


 

Identification Of Viral Pathogens Responsible For Severe And Complicated Respiratory Infection During The Pandemic And Post-Pandemic Period (2009-2011)

Marta Canuti et al.

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.

ECV 2013


 

Development of a new diagnostic tool for the detection of Human Coronaviruses & Human Parainfluenzaviruses in a duplex RT PCR

Jérôme Bes et al.

bioMérieux.

ECV 2013


 

Development of a new diagnostic tool for the detection of Rhinovirus/Enterovirus and Cellular control in a duplex RT PCR

Bes et al. ARGENE.

Europic 2012


 

Development of a new diagnostic tool for the detection of Chlamydophila pneumoniae and Mycoplasma pneumoniae in a duplex real-time PCR

Bertrand et al.

ARGENE.

ECCMID 2012


 

Respiratory Multi Well System (MWS) r-gene™ : simultaneous detection of infectious agents involved in respiratory diseases

Magro et al.

ARGENE.

CVS 2011


 

Respiratory Multi Well System (MWS) r-gene™ : simultaneous detection of infectious agents involved in respiratory diseases

Résa et al.

ARGENE.

ESCV 2011


 

Development of a new diagnostic tool for the detection of Chlamydophila pneumoniae and Mycoplasma pneumoniae in a duplex real-time PCR

Bertrand et al.

ARGENE.

ESCV 2011


 

 

Please consult your local bioMérieux representative for product availability in your country

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