VIDAS® Dengue panel

3 automated tests for accurate diagnosis

The VIDAS® Dengue panel includes 3 immunoassays, targeting the biomarkers recommended by the international guidelines1 to cover the largest detection window for early and accurate diagnosis of dengue.

  • Complete solution: NS1, IgM and IgG detection
  • Affordable in resource-limited settings
  • Proven reliable and objective results
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A complete solution for dengue diagnosis – Accessible to all labs

According to WHO estimates, the dengue virus infects 100 to 400 million people worldwide every year, and it is rapidly spreading. A leading cause of serious illness and death in Asia and Latin America, dengue now affects new areas, including Europe. Early detection of disease progression associated with severe dengue is essential to reduce fatality rates. However, symptoms are not specific, and can be easily confused with other infection diseases such as malaria, chikungunya, Zika or yellow fever.

The VIDAS® Dengue panel includes the 3 serological tests recommended by international guidelines1 for accurate and early diagnosis. Accessible to all labs, they allow rapid and reliable confirmation or exclusion of dengue infection for optimized patient management and early response to severe disease.

A complete solution for dengue diagnosis

3 complementary tests :

NS1:  NS1 is an early and sensitive viral marker of acute infection. It is the best solution for virus detection adapted to labs with no access to RT-PCR. 
IgM:  If IgM appears earlier than IgG, it also disappears earlier. This makes IgM an early marker of acute primary infection.
IgG: IgG is widely used to determine the presence of specific immunity.

 

Kinetics of Dengue virus (genome/NS1 antigen) and antibodies (IgM & IgG)

 

During the early phase of the disease, direct diagnostic techniques such as NS1 are preferred. Moreover, combining NS1 detection with IgM serology in routine diagnosis of dengue virus infection can help improve accuracy of dengue diagnosis2,3.

   ➔ Importance to combine NS1 and IgM and eventually IgG (for secondary infection)

In Post-acute phase, after 5-7 days post onset of symptoms, serological tests based on the patient’s immune response to infection (IgM and/or IgG) are commonly used4.

   ➔ Importance to combine IgM & IgG

With VIDAS, choose your own combination of tests.

 

Proven high performance 

Based on bioMérieux’s strong expertise in Infectious Diseases, the VIDAS® Dengue panel offers high-quality reagents for reliable and clear-cut results:

VIDAS® Dengue NS1 Ag VIDAS® Anti-Dengue IgM VIDAS® Anti-Dengue IgG
Sensitivity equivalent to ELISA method5 Good specificity without endogenous interferences6 (rheumatoid factor, antinuclear antibodies, …) No cross reactivity with chikungunya, Zika, yellow fever and malaria7
Overall percent agreement = 96.4%5

Positive percent agreement combined IgG/IgM = 91.9%6,7

Excellent performance on all dengue virus serotypes for confirmation or exclusion of dengue infection

No equivocal zone

The clinical study has been performed with samples from endemic populations below :

  • Latin America
  • Africa
  • Asia

In conclusion, the performance in the package inserts is representative  of the most endemic areas.

 

Accessible to all labs

The VIDAS® Dengue panel is available on the VIDAS® automated benchtop immunoanalyzers, trusted around the world for their robustness, reliability and 24/7 availability.

It provides a cost-effective, flexible and easy-to-use solution to automatize dengue diagnosis:

  • Independent assays
  • Single-dose, ready-to-use tests
  • Just load & go
  • Objective, automated result interpretation
  • Small, all-inclusive kits with long shelf life

Choose your own combination of tests for each patient!

 

References:

1. WHO,

2. Hunsperger EA, et al. PLoS Negl Trop Dis 2014;8(10):e3171

3. PAHO Dengue testing guidelines

4. VIDAS® Dengue NS1 Ag package insert

5. VIDAS® Anti-Dengue IgM package insert

6. VIDAS® Anti-Dengue IgG package insert

  VIDAS® Dengue NS1 Ag VIDAS® Anti-Dengue IgM VIDAS® Anti-Dengue IgG
Reference 423077 423078 423079
Tests / kit 60 60 60
Sample type Serum Serum Serum
Calibration frequency Only 56 days Only 56 days Only 56 days
Shelf life 18 months 18 months 18 months

Consult your local bioMérieux representative for product availability in your country

Accessible to all labs

The VIDAS® Dengue panel is available on the VIDAS® automated benchtop immunoanalyzers, trusted around the world for their robustness, reliability and 24/7 availability.

It provides a cost-effective, flexible and easy-to-use solution to automatize Dengue diagnosis:

  • Independent assays
  • Single-dose, ready-to-use tests
  • Just load & go
  • Objective, automated result interpretation
  • Small, all-inclusive kits with long shelf life

Choose your own combination of tests for each patient!

 

References:

1. WHO,

2. Hunsperger EA, et al. PLoS Negl Trop Dis 2014;8(10):e3171

3. PAHO Dengue testing guidelines 4. VIDAS® Dengue NS1 Ag package insert

5. VIDAS® Anti-Dengue IgM package insert

6. VIDAS® Anti-Dengue IgG package insert

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Accessible to all labs

The VIDAS® Dengue panel is available on the VIDAS® automated benchtop immunoanalyzers, trusted around the world for their robustness, reliability and 24/7 availability.

It provides a cost-effective, flexible and easy-to-use solution to automatize Dengue diagnosis:

  • Independent assays
  • Single-dose, ready-to-use tests
  • Just load & go
  • Objective, automated result interpretation
  • Small, all-inclusive kits with long shelf life

Choose your own combination of tests for each patient!

 

References:

1. WHO,

2. Hunsperger EA, et al. PLoS Negl Trop Dis 2014;8(10):e3171

3. PAHO Dengue testing guidelines 4. VIDAS® Dengue NS1 Ag package insert

5. VIDAS® Anti-Dengue IgM package insert

6. VIDAS® Anti-Dengue IgG package insert

Please consult your local bioMérieux representative for product availability in your country

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